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I believe that an integrated approach focusing the cellular and molecular mechanisms underlying the disease state is crucial for the full understanding of the pathology, and to develop effective therapeutic approaches.

Purkinje Cells

Purkinje Cells

Purkinje cells label with calbindin antibody (mouse cerebellum; confocal microscopy)

Neuroblastoma cells

Neuroblastoma cells

N2a cells label with G3BP1 antibody after stress granules induction (laser microscopy)

Fibroblast with Golgi

Fibroblast with Golgi

Fibroblast label with GM130 antibody depicting the Golgi complex around the nucleus (laser microscopy)

Purkinje cells

Purkinje cells

Purkinje cells depicting small protein aggregates label with HA antibody (mouse cerebellum, confocal microscopy)

Fibroblast

Fibroblast

Fibroblast label with GM130 (green) and Atx2 (red) antibodies (laser microscopy)

Neurons derived from iPSc

Neurons derived from iPSc

Neurons derived from iPSc label with G3BP1 after stress granules induction (confocal microscopy)

Neuroblastoma cells

Neuroblastoma cells

N2a cells showing protein aggregates in the nucleus (laser microscopy)

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