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Clévio Nóbrega
Biomedical and Life Sciences Researcher, PhD
Carmo-Silva S, Nóbrega, Clévio, de Almeida, LP, Cavadas C (2017). Unravelling the role of ataxin-2 in Metabolism. Trends Endocrinol. Metab. 28:309-318.
Matos, CA, de Almeida, LP, Nóbrega, Clévio (2017). Proteolytic cleavage of Polyglutamine disease-causing proteins: revisiting the toxic fragment hypothesis. Curr Pharm Des. 23: 753-755.
Nóbrega Clévio, Khadem M, Aguade M, Segarra C (2008) Genetic exchange versus genetic differentiation in a medium-sized inversion of Drosophila: the A2/Ast arrangements of Drosophila subobscura. Mol Biol Evol 25:1534-1543.
Alves S, Nascimento-Ferreira I, Dufour N, Hassig R, Auregan G, Nóbrega Clévio, Brouillet E, Hantraye P, Pedroso de Lima MC, Deglon N, de Almeida LP (2010) Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Hum Mol Genet 19:2380-2394.
Khadem M, Camacho R, Nóbrega Clévio (2011) Studies of the species barrier between Drosophila subobscura and D. madeirensis V: the importance of sex-linked inversion in preserving species identity. J Evol Biol 24:1263-1273.
Sousa-Ferreira L, Garrido M, Nascimento-Ferreira I, Nóbrega Clévio, Santos-Carvalho A, Álvaro AR, Rosmaninho-Salgado J, Kaster M, Kügler S, de Almeida LP, Cavadas C (2011) Moderate long-term modulation of Neuropeptide Y in the Arcuate Nucleus induces energy balance alterations in adult rats. PLoS One, 6:e22333.
Albuquerque D, Nóbrega Clévio, Samouda H, Manco L (2012) Assessment of obesity and abdominal obesity among Portuguese children. Acta Med. Port. 25(3):169-73.
Albuquerque D, Nóbrega Clévio, Manco L (2013) The lactase persistence -13190 C>T polymorphism shows indication of association with abdominal obesity among Portuguese children. Acta Paediatr, 10:e153-7.
Albuquerque D, Nóbrega Clévio, Manco L (2013) Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children. PLoS One 8(1):e54370.
Nóbrega Clévio, Nascimento-Ferreira I, Onofre I, Albuquerque D, Conceição M, Déglon N, Pereira de Almeida L (2013) Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology. Cerebellum, 12:441-55.
Costa PM, Cardoso AL, Nóbrega Clévio, Pereira de Almeida L, Bruce JN, Cannol P, Pedroso de Lima MC (2013) MicroRNA-21 silencing enhances the cytotoxic effect of the antiangiogenic drug sunitinib in gliobastoma. Hum.Mol.Genet 22:904-18.
Nóbrega Clévio, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, Pereira de Almeida L (2013) Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice. PLoS One 8(1):e52396.
Nascimento-Ferreira I*, Nóbrega Clévio*, Ferreira-Vasconcelos A, Onofre I, Albuquerque D, Aveleira C, Hirai H, Déglon N, Pereira de Almeida L (2013) Beclin-1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease. Brain, 136:2173-88. *Equal contribution.
Albuquerque D, Nóbrega Clévio, Rodriguez-López R, Manco L (2014) Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children. J Hum Genet, 59:307-13.
Albuquerque D, Estévez MN, Víbora PB, Giralt PS, Balsera AM, Cortés PG, López MJ, Luego LM, Gervasini G, Hernández SB, Arroyo-Díez J, Vacas MA, Nóbrega Clévio, Manco L, Rodríguez-López R (2014) Novel variants in the MC4R and LEPR genes among severly obese children from the Iberian population. Ann Human Genet, 78:195-207.
Nóbrega Clévio, Nascimento-Ferreira I, Onofre I, Albuquerque D, Hirai H, Déglon N, Pereira de Almeida L (2014) RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease. PlosOne, 9(8):e100086.
Albuquerque D, Stice E, Rodríguez-López R, Manco L, Nóbrega Clévio (2015). Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective. Mol.Genet.Genomics, 290:1191-221.
Mendonça L, Nóbrega Clévio, Hirai H, Kaspar B, Pereira de Almeida L (2015) Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in a transgenic mouse model of Machado-Joseph disease. Brain, 138:320-35.
Aveleira C, Botelho M, Carmo-Silva S, Pascoal J, Ferreira-Marques M, Nóbrega Clévio, Cortes L, Valero J, Sousa-Ferreira L, Álvaro AR, Santana M, Kugler S, Pereira de Almeida L, Cavadas C (2015). Neuropepetide Y stimulates autophagy in hypothalamic neurons. PNAS USA,112:E1642-51.
Nóbrega Clévio, Carmo-Silva S, Albuquerque D, Vasconcelos-Ferreira A, Vijayakumar U-G, Mendonça L, Hirai H, Pereira de Almeida L (2015). Reestablishing Ataxin -2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease. Brain, 138:3537-54. Editor’s Choice, December 2015 Highlight
Conceição, M, Mendonça, L, Nóbrega, Clévio, Gomes, C, Costa, P, Hirai, H, Moreira, JN, Lima, C, Manjunath, N, Pereira de Almeida, L. (2016). Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype. Biomaterials, 82:124-137.
Matos, CA, Nóbrega Clévio, Louros SR, Almeida B, de Almeida, LP, Macedo-Ribeiro S, Carvalho AL. (2016). Ataxin-3 phosphorylation decreases neuronal defects and toxicity in spinocerebellar ataxia type 3 disease models. J Cell Biol, 212:465-480.
Conceição, M, Mendonça, L, Nóbrega, Clévio, Gomes, C, Costa, P, Hirai, H, Moreira, JN, Lima, C, Manjunath, N, Pereira de Almeida, L. (2016). Safety profile fo the intravenous administration of brain-targeted stable nucleic acid lipid particles. Data Brief., 6:700-705.
Alves Cruzeiro, J, Mendonça, L, Pereira de Almeida, L, Nóbrega, Clévio (2016). Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: a Comprehensive Review. Frontiers in Neuroscience, 10:532.
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